Medical Genetics of Colon Cancer
https://www.amazon.com/Medical....-Genetics-Cancer-App This article collection reviews the medical genetics of colon cancer and includes 18 papers by various authors. Topics include: Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions; Breakpoint characterization of a novel large intragenic deletion of MUTYH detected in a MAP patient: Case report; Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?; Simplifying the detection of MUTYH mutations by high resolution melting analysis; Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin; Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion; Genotyping panel for assessing response to cancer chemotherapy; Early-onset colorectal cancer patients without family history are “at very low risk” for lynch syndrome; Hereditary Colorectal Cancer in China; Some aspects of molecular diagnostics in Lynch syndrome; Abstracts from the 10th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer, November 9-10, 2006, Nashville, Tennessee, United States; MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer; Drug therapy for hereditary cancers; Germline deletions in the EPCAM gene as a cause of Lynch syndrome – literature review; Hereditary cancer risk assessment: essential tools for a better approach; Colorectal cancer and self-reported tooth agenesis; Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk; Design and validation of an oligonucleotide microarray for the detection of genomic rearrangements associated with common hereditary cancer syndromes.
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