INTRAPLEURAL CHEMOTHERAPY MESOTHELIOMA

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07/02/23

INTRAPLEURAL CHEMOTHERAPY MESOTHELIOMA
➡️ http://MesotheliomaUSA.net

Surgery is one of the steps of multimodality approach for the treatment of MPM. Due to anatomical features, microscopically radical (R0) resection is never possible and a Macroscopic Complete Resection (R1) is considered the target for mesothelioma surgeons. Recently, intracavitary therapies have been described with the aim of extending the loco-regional effect of surgery. Different agents might be administered intrapleurally: chemotherapy drugs are the most widely used, but also photodynamic therapy (PDT) showed to lead to satisfactory long-term outcomes; furthermore, immunotherapies and gene therapies have been also reported. Despite promising results, no high-quality evidences are currently available and controlled randomized trials are required to establish the exact role of intracavitary therapies and to standardize the technique.

Keywords: Malignant pleural mesothelioma (MPM), multimodality treatment, surgery, intracavitary therapy

0:08 Abstract
1:10 Introduction
3:08 Intrathoracic therapies
3:36 Chemotherapeutic agents and hyperthermia
7:29 Povidone iodine
8:25 Photodynamic therapy (PDT)
10:45 Intrapleural immunotherapies
12:38 Gene therapy
13:16 Conclusions

INTRAPLEURAL CHEMOTHERAPY MESOTHELIOMA
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🔗 https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC58305