Incidence of Gastrointestinal neuroendocrine tumors (GI-NETs)

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07/09/23

The incidence of Gastrointestinal neuroendocrine tumors (GI-NETs) has been increasing in recent years.

Gastric NETs (G-NETs) are classified into three distinct subgroups: type I, II, and III.
Type I G-NETs are the most common subtypes and are associated with chronic atrophic gastritis, (autoimmune gastritis and Helicobacter pylori-associated atrophic gastritis).

Type II G-NETs are associated with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome.
Endoscopic resection and follow-up are amenable treatment options for most type I and II G-NETs.

In contrast, type III G-NETs are large-sized single tumors and are usually malignant. Therefore, surgical resection and chemotherapy are generally necessary for type III G-NETs.

Here, we demonstrate a recent case presenting with multiple Gastric NETs (low grade with no metastasis) who underwent complete margin-free endoscopic resection using EMR for smaller and ESD for larger NET.

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Dr. Shrihari Anikhindi is a Gastroenterologist and Hepatologist at Sir Ganga Ram Hospital and Medigest, New Delhi.

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