Gliomas Brain tumors (Neurology): Expert Talk by Dr. Krishna Kumar (Consultant Neurosurgeon )

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06/25/23

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Gliomas (Neurology) : Expert Talk by Dr. Krishna Kumar ( Consultant Neurosurgeon )

Gliomas account for the great majority of primary tumors that arise within the brain parenchyma. The term "glioma" refers to tumors that have histologic features similar to normal glial cells (ie, astrocytes, oligodendrocytes, and ependymal cells). For each of these types of gliomas, there are neoplasms that span a broad spectrum of biological aggressiveness.

Historically, the slower-growing lesions, corresponding to World Health Organization (WHO) grades I and II, have been commonly referred to as low-grade gliomas, while the more rapidly progressive tumors are referred to as high-grade gliomas. The WHO classification recommends avoiding these terms since they lump together heterogeneous groups of tumors, many of which have significantly different biologic properties, prognoses, and treatment approaches. Among grade I and grade II gliomas, for example, current classification favors a distinction between diffuse gliomas (eg, grade II diffuse astrocytoma and oligodendroglioma) and more circumscribed astrocytic tumors (eg, grade I pilocytic astrocytoma). Additionally, it is clear that among grade III and grade IV tumors, there can be markedly different courses, including responses to therapies.

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