DNA repair, cancer and aging - Martin Kosar, IFOM
Martin Kosar has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 707600.
Each cell in the human body is continuously exposed to various factors causing DNA damage. Some DNA aberrations arise via physiological processes (DNA replication, oxidative respiration), others are triggered by environmental insults (sun-light, food contaminants and smoke). Changes in DNA can result in permanent mutations if left unrepaired. Therefore, cells have evolved several mechanisms to detect and repair the various types of damage that can occur to DNA. Emerging evidence suggests that defects in DNA repair are strongly associated with cancer and aging. How are DNA lesions dealt with at the molecular level? Which is the role of DNA repair mechanisms in preventing human diseases? During the seminar we will illustrate how our increasing knowledge of DNA-damage responses is providing opportunities to design novel strategies for cancer therapy and anti-aging drug discovery.
L'evento fa parte del ciclo di incontri organizzato da Youscientist, il programma divulgativo di IFOM, nel 2018.
https://www.ifom.eu/it/scienza....-societa/conferenze-
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