Alzheimer's Amyloid Hypothesis Swirling in Controversy
(Animation & audio: public domain, U.S. NIH) Titles & article by AlzheimerWeekly.com: http://www.alzheimersweekly.co....m/2015/05/controvers
In 1984, the "Amyloid Hypothesis" fingered amyloid-beta plaque as the culprit behind Alzheimer's. 30 frustrating years later, we haven't found the cure, yet amyloid remains the #1 suspect. Are we barking up the wrong tree? Is it time for research to change course? A new study takes a look at the arguments. Read the pros and cons.
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A new study reviews the huge body of research proposing that the accumulation of beta amyloid triggers Alzheimer's disease in the brain. The study appears in an open access, peer-reviewed title from Future Science Group.
In 1984, a study by Glenner and Wong can be said to have initiated the "Amyloid Hypothesis". It suggested that plaque on the brain made out of beta-amyloid was the trigger behind Alzheimer's.
Once the target was identified, scientists naturally zoomed in on it to try and cure Alzheimer's.
Today, the search for the cure has led to hundreds of failed trials. Is the Amyloid Hypothesis to blame? Is it lacking or even wrong? Here is an update on the Pros-and-Cons of the Amyloid Hypothesis and how it affects the search for an Alzheimer's cure.
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YouTube limits the amount of text here. For the entire article, footnotes and Executive Summary, go to the original at:
http://www.alzheimersweekly.co....m/2015/05/controvers
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