10 - Ricardo Hitt - Squamous Cell Head & Neck Cancer

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08/09/23

1 Squamous Cell H&N Cancer-- Hypopharynx
2 Treatment of HNC: Multidisciplinary
3 Standard treatment options for HNC
4 Locoregional control and distant metastases
5 Hypopharyngeal cancer
6 Hypopharyngeal cancer: objectives
7 EORTC 24891 Ph III: PF + RT vs surgery + RT
8 EORTC 24891: Patient characterisics
9 EORTC 24891: Overal survival and DFS
10 Survival Pharyngeal SCC after definitive RT
11 Standard treatment for LA SCCHN
12 ASCO 1982: The Platinum Revolution
13 Rationale for induction CT
14 Al-Sarraf: Induction 5-FU and Cisplatin
15 MACH-NC meta analysis: CT and 5-Year Survival
16 How can we improve the results?
17 EORTC 24971/TAX 323 Ph III: Ind. CT + RT
18 TAX 324 Ph III: Ind. CT - CRT - Surgery
19 HNSCC: Taxotere in Locally-Advanced Disease
20 Phase III: PF ± Docetaxel vs CRT
21 CR to induction CT/CRT -- same benefit in survival?
22 Standard treatment
23 Conclusions