The management of patients with transthyretin amyloidosis includes 2 main categories of disease-modifying therapies. This video discusses the role of TTR stabilizers and TTR silencers/knockdown agents along with heart failure and arrhythmia management for the management of patients with cardiac ATTR.

Please visit our post-module evaluation survey as well!
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Giada Bianchi, MD, provides an overview on AL amyloidosis and discusses new treatment options available for patients.

Learn more about our AL Amyloidosis Program: https://www.dana-farber.org/ca....ncer-care/treatment/

Thousands of people have varying types of transthyretin amyloidosis (ATTR) around the world including polyneuropathy (ATTRv-PN), but it is still an underdiagnosed disease.

One patient diagnosed with ATTR, David, shares his family history with the disease and discusses challenges and symptoms he’s been managing with his care team. https://www.astrazeneca.com/me....dia-centre/articles/

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Amyloidosis (am-uh-loi-DO-sis) is a rare disease that may affect the heart, kidneys, liver, spleen, nervous system and digestive tract. Learn more about this complex and serious condition.

Please visit our post-module evaluation survey as well!
Link to survey: https://www.surveymonkey.com/r/8RL5D9K

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Premium Member Resources: https://ninjanerd.org

Ninja Nerds,
Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Amyloidosis, a complex disorder characterized by the misfolding and deposition of insoluble amyloid fibrils in tissues. We break down the different subtypes, including AL (light chain), AA (secondary), ATTR (transthyretin), and Aβ2M (β2 microglobulin), highlighting their unique pathogenesis, clinical manifestations, and diagnostic approaches.

Our discussion covers the systemic vs. localized forms of the disease, exploring how amyloid deposition can impact critical organs like the heart (restrictive cardiomyopathy), kidneys (nephrotic syndrome), nervous system (autonomic and peripheral neuropathy), and gastrointestinal tract. We also walk through essential diagnostic tools, including serum and urine electrophoresis, fat pad biopsy with Congo red staining, mass spectrometry, and advanced imaging techniques like cardiac MRI and PYP scanning for ATTR amyloidosis.

Finally, we break down the latest treatment strategies, from chemotherapy and autologous stem cell transplant for AL amyloidosis. Whether you’re preparing for exams, rotations, or just want to master this challenging topic, this episode is packed with high-yield insights to boost your understanding!

Enjoy the episode and support us below! 💡🔥

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#ninjanerd #hematology #amyloidosis

"Way Maker" led by Paul McClure

This Single now available on all platforms:
https://bethelmusic.lnk.to/WayMakerYT

Worship Leader - Paul McClure | @paulmcclure
2nd Worship Leader - Jenn Johnson | @jennjohnson20
Keys - Luke Hendrickson | @thelukehendy
Electric Guitar - David Hislop | @davidhislop
Strings - Allison Marin | @allisonandantonio
Drums - Viktor Pilipovich | @viktor_pili
Bass - Adam Kiser | @theadamkiser

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Lyrics:

|Verse 1|
You are here, moving in our midst
I worship You, I worship You
You are here, working in this place
I worship You, I worship You
You are here, moving in our midst
I worship You, I worship You
You are here, working in this place
I worship You, I worship You

|Chorus|
You are
Waymaker, miracle worker
Promise keeper, light in the darkness
My God, that is who You are
You are
Waymaker, miracle worker
Promise keeper, light in the darkness
My God, that is who You are

|Verse 2|
You are here, touching every heart
I worship You, I worship You
You are here, healing every heart
I worship You, I worship You

[Verse 3]
You are here, turning lives around
I worship You, I worship You
You are here, mending every heart
I worship You, I worship You

|Refrain|
That is who You are (That is who You are)
That is who You are (That is who You are)

Writer:
Osinachi Kalu Okoro Egbu

#WayMaker #bethelmusic